LITTLE KNOWN FACTS ABOUT PKRRATING.

The activated enzyme then phosphorylates its big substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved spouse and children of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to distinctive stimuli12, triggering the b